A convenient method for cyanation of aromatic iodo compounds

Abstract

Abstract A variety of [ 13 C]‐labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [ 13 C]‐cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre‐prepared carbon‐labelled copper (I) cyanide was therefore obviated.