Concepedia

A convenient method for cyanation of aromatic iodo compounds

Richard M. Carr, Karl M. Cable, Guy N. Wells, Derek R. Sutherland

Journal of Labelled Compounds and Radiopharmaceuticals · 1994 · 21 citations · 5 references

DOI

Concepts

Abstract

Abstract A variety of [ 13 C]‐labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [ 13 C]‐cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre‐prepared carbon‐labelled copper (I) cyanide was therefore obviated.

References

5

Dimethylformamide as a Useful Solvent in Preparing Nitriles from Aryl Halides and Cuprous Cyanide; Improved Isolation Techniques<sup>1a</sup>

Lester Friedman, Harold Shechter · The Journal of Organic Chemistry · 1961 · 242 citations

, , +4

Nucleophilic Displacement Catalyzed by Transition Metal. I. General Consideration of the Cyanation of Aryl Halides Catalyzed by Palladium(II)

Kentaro Takagi, Tadashi Okamoto, Yasumasa Sakakibara et al. · Bulletin of the Chemical Society of Japan · 1975 · 108 citations

, , +16

Notes- N-Methylpyrrolidone as Solvent for Reaction of Aryl Halides with Cuprous Cyanide.

Melvin S. Newman, Herbert Boden · The Journal of Organic Chemistry · 1961 · 74 citations

, , +4

Mechanisms and models for homogeneous copper mediated ligand exchange reactions of the type: CuNu + ArX → ArNu + CuX

Christiane Couture, Anthony J. Paine · Canadian Journal of Chemistry · 1985 · 63 citations

, , +16

Synthesis of carbon‐14 and tritium labelled analogs of the noval antischizophrenic agent clozapine

Ustun B. Sunay, Kenrick C. Talbot, Vincent Galullo · Journal of Labelled Compounds and Radiopharmaceuticals · 1992 · 13 citations

, , +9