The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation.

Abstract

Iagent has been known for a number of years. scribed elsewhere (4). The test organs in the I However, the first reference to testing of canine experiments were the kidney and I antiserums for homograft protection was by liver. The clinical patients had renal hoI Woodruff, who later published with Ander- motransplantation. son (20, 21) detailed observations of the I effect of these agents used alone or in cornI bination with thoracic duct drainage. Sub- Canine experiments. One hundred and sequent valuable studies have been con- &my-four mongrel dogs weighing 10 to 25 tributed by Waksman, Gray (2), Monaco kilograms were immunized against hepatitis (9, 10) and their respective associates and by and distemper and used as homograft reJeejeebhoy, Nagaya and Sieker, and Levey cipients. Operations were performed under and Medawar (6, 7). The experimental sodium pentobarbital anesthesia combined model for the foregoing experiments con- with the tranquilizer phencyclidine hydrosisted of skin grafting in mice, rats, or guinea chloride. Renal transplants were accompigs which were treated with antiserums plished by transferring the donor kidney to raised in rabbits. Except for our own brief the contralateral recipient iliac fossa, with report (14) and those of Abaza, and Mitchell anastomoses of the renal artery to the proxiand their colleagues there are no published mal end of the cut common iliac artery, the accounts on the use of antilymphoid serum renal vein to the side of the common iliac I