Concepedia

(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier, Alexandros Makriyannis

Molecular Pharmacology · 2005 · 98 citations · 37 references

DOI

Concepts

References

37

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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, , +14

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Krzysztof Palczewski, Takashi Kumasaka, Tetsuya Hori et al. · Science · 2000 · 5.6K citations

, , +16

A graphic method for the determination and presentation of binding parameters in a complex system

Hannah Rosenthal · Analytical Biochemistry · 1967 · 1.5K citations

, , +13

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

David Farrens, Christian Altenbach, Ke Yang et al. · Science · 1996 · 1.2K citations

, , +17

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

Juan Antonio Ballesteros‐Cánovas, Anne D. Jensen, George Liapakis et al. · Journal of Biological Chemistry · 2001 · 619 citations · Full text

, , +17