Protein Expression, Aggregation, and Triggered Release from Polymersomes as Artificial Cell‐like Structures

Chiara Martino, Shin‐Hyun Kim, Louise Horsfall, Alireza Abbaspourrad, Susan J. Rosser, Jonathan M. Cooper, David A. Weitz

Angewandte Chemie International Edition · 2012 · 182 citations · 28 references

Concepts

Abstract

Bringing droplets to life: A cytoskeletal protein (red dots, see scheme) is expressed in artificial cells composed of biocompatible polymersomes, which encapsulate expression machinery and amino acid building blocks. Release of the expressed proteins can be triggered by a negative osmotic shock.

References

28