Concepedia

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention

Katrien O. François, Kris Covens, Kristel Van Laethem, Jan Balzarini

Virology · 2008 · 33 citations · 49 references

DOI

Concepts

References

49

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature · 1998 · 3K citations · Full text

, , +12

The antigenic structure of the HIV gp120 envelope glycoprotein

Richard T. Wyatt, Peter D. Kwong, Elizabeth Desjardins et al. · Nature · 1998 · 1.2K citations · Full text

, , +9

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

Alexandra Trkola, Martin Purtscher, Thomas Muster et al. · Journal of Virology · 1996 · 1.1K citations · Full text

, , +12

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.

C K Leonard, Michael W. Spellman, L Riddle et al. · Journal of Biological Chemistry · 1990 · 980 citations · Full text

, , +17

Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1

Stephen S. Hwang, Terence J. Boyle, H. Kim Lyerly et al. · Science · 1991 · 864 citations

, , +17