Proviral Integration Site <i>Mis-1</i> in Rat Thymomas Corresponds to the <i>pvt-1</i> Translocation Breakpoint in Murine Plasmacytomas

Abstract

Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.