Dopamine, but Not Norepinephrine or Serotonin, Reuptake Inhibition Reverses Motor Deficits in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Primates

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Richard S. Burns, Chuang C. Chiueh, Sanford P. Markey et al. · Proceedings of the National Academy of Sciences · 1983 · 2.1K citations · Full text

Medicine, Neuroscience, Pharmacology +17

A Five-Year Study of the Incidence of Dyskinesia in Patients with Early Parkinson's Disease Who Were Treated with Ropinirole or Levodopa

Olivier Rascol, David J. Brooks, Amos D. Korczyn et al. · New England Journal of Medicine · 2000 · 1.5K citations · Full text

Medicine, Neurology, Pharmacotherapy +11

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

J. William Langston, Lysia S. Forno, Charles S. Rebert et al. · Brain Research · 1984 · 919 citations

Medicine, Pharmacology, Toxicology +5

Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease

B. Scatton, France Javoy‐Agid, L. Rouquier et al. · Brain Research · 1983 · 725 citations

Life Sciences, Neurology, Neuroscience +12

Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake

Elliott Richelson, Michael Pfenning · European Journal of Pharmacology · 1984 · 530 citations

Medicine, Neuroscience, Pharmacology +17