The Kinetics of Inhibition of Human Acetylcholinesterase and Butyrylcholinesterase by Two Series of Novel Carbamates

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

William K. Summers, Lawrence V. Majovski, Gary M. Marsh et al. · New England Journal of Medicine · 1986 · 1.2K citations

Medicine, Neurology, Pharmacology +15

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

Yvain Nicolet, Oksana Lockridge, Patrick Masson et al. · Journal of Biological Chemistry · 2003 · 830 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

Zoran Radić, Natilie A. Pickering, Daniel C. Vellom et al. · Biochemistry · 1993 · 439 citations

Medicine, Medicinal Chemistry, Pharmacology +11