Concepedia

First C-3 lithiation of DMAP: a new entry into chemical tuning of acylation catalysts

Philippe C. Gros, Abdelatif Doudouh, Christopher J. Woltermann

Chemical Communications · 2006 · 18 citations · 14 references

DOI

Concepts

Abstract

A TMSCH2Li-based reagent promoted the first C-3 lithiation of DMAP opening a direct access to functional diversity in acylation catalysts.

References

14

4‐Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)]

Gerhard Höfle, Wölfgang Steglich, Helmut Vorbrüggen · Angewandte Chemie International Edition in English · 1978 · 1.2K citations

, , +16

The Synthesis of Aminopyridines:  A Method Employing Palladium-Catalyzed Carbon−Nitrogen Bond Formation

Seble Wagaw, Stephen L. Buchwald · The Journal of Organic Chemistry · 1996 · 357 citations

, , +9

Nickel-Catalyzed Amination of Aryl Chlorides

John P. Wolfe, Stephen L. Buchwald · Journal of the American Chemical Society · 1997 · 348 citations

, , +14

Development of Chiral Nucleophilic Pyridine Catalysts:  Applications in Asymmetric Quaternary Carbon Synthesis

Scott A. Shaw, P. Aleman, Edwin Vedējs · Journal of the American Chemical Society · 2003 · 261 citations

, , +16

Kinetic Resolution of Secondary Alcohols. Enantioselective Acylation Mediated by a Chiral (Dimethylamino)pyridine Derivative

Edwin Vedējs, Xinhai Chen · Journal of the American Chemical Society · 1996 · 236 citations

, , +10