British Journal of Haematology · 1995 · 199 citations · 11 references
MedicineImmunologyObstetricsClinical BiochemistryMaternal-fetal MedicineReproductive ImmunologyAnticoagulant TherapyCoagulation AbnormalitiesPregnancyPregnancy ImmunologyThrombosisThrombosis PreventionActivated Protein C ResistanceGestation PeriodObstetric ThromboprophylaxisPlasma Anticoagulant ActivityPregnancy-associated ThromboprophylaxisProtein C Pathway ImpairmentProtein C SystemThrombosis Prevention In Pregnancy
We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14-20, 28 and 36 weeks gestation, and at 1 d post-partum. Significant reductions in the mean APC sensitivity ratio (APC-SR) were observed at all stages of pregnancy studied compared with the mean APC-SR obtained for baseline measurements carried out at > 8 weeks post-partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14-20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.
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Mutation in blood coagulation factor V associated with resistance to activated protein C
Rogier M. Bertina, Bobby P. C. Koeleman, Ted Koster et al. · Nature · 1994 · 3.8K citations
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Björn Dahlbäck, Martin Carlsson, Peter J. Svensson · Proceedings of the National Academy of Sciences · 1993 · 2K citations
Ted Koster, FR Rosendaal, Hans de Ronde et al. · The Lancet · 1993 · 1.3K citations
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