Concepedia

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

Sean L. McGee, Bryce J. W. van Denderen, Kirsten F. Howlett, Janelle P. Mollica, Jonathan D. Schertzer, Bruce E. Kemp, Mark Hargreaves

Diabetes · 2008 · 442 citations · 42 references

DOIFull text

Open access

Abstract

These data reveal a signal transduction pathway linking cellular energy charge to gene transcription directed at restoring cellular and whole-body energy balance and provide new therapeutic targets for the treatment and management of insulin resistance and type 2 diabetes.

References

42

Global Prevalence of Diabetes

Sarah H. Wild, Gojka Roglić, Anders Green et al. · Diabetes Care · 2004 · 15.2K citations

A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

Matthew G. Guenther, Stuart S. Levine, Laurie A. Boyer et al. · Cell · 2007 · 1.9K citations · Full text

, , +14

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

, , +11

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Mhairi C. Towler, D. Grahame Hardie · Circulation Research · 2007 · 1.2K citations · Full text

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

Timothy A. McKinsey, Chun‐Li Zhang, Jianrong Lu et al. · Nature · 2000 · 1.1K citations · Full text

, , +15