Deletion of a Small Consensus Region at 6q15, Including the<i>MAP3K7</i>Gene, Is Significantly Associated with High-Grade Prostate Cancers

Abstract

Our study provides strong evidence for the first time that a small deletion at 6q15, including the MAP3K7 gene and four other genes, is associated with high-grade prostate cancers. Although the deletion may be a marker for high-grade prostate cancer, additional studies are needed to understand its molecular mechanisms.