Association of the Exon 3 Deleted/Full-Length<i>GHR</i>Polymorphism with Recombinant Growth Hormone Dose in Growth Hormone-Deficient Adults

Abstract

The d3-allele carriers required approximately 25% less exogenous GH compared with the homozygous fl-allele carriers, which may express an increased responsiveness to exogenous GH. Variability of the individually required GH dose in adult GH-deficient patients may therefore be partly due to the GHRd3/fl polymorphism. Further studies are required to confirm these results.