Concepedia

Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

Xin Gu, Jasminka Dragovic, Gloria C. Koo, Sam L. Koprak, Cheryl B. LeGrand, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Eugene Y. Tan, Rolf Thieringer,

Bioorganic & Medicinal Chemistry Letters · 2005 · 54 citations · 14 references

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14

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science · 2001 · 1.8K citations

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11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Yuri Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences · 1997 · 855 citations

, , +17

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Nicholas M. Morton, Janice M. Paterson, Hiroaki Masuzaki et al. · Diabetes · 2004 · 504 citations · Full text

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Metabolic Syndrome

Gerald M. Reaven · Circulation · 2002 · 496 citations

Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

Nicholas M. Morton, Megan C. Holmes, Catherine Fiévet et al. · Journal of Biological Chemistry · 2001 · 437 citations · Full text

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