Fast, solvent-free, highly enantioselective three-component coupling of aldehydes, alkynes, and amines catalysed by the copper(<scp>ii</scp>)pybox complex under high-vibration ball-milling

Abstract

Chiral propargylamines were prepared by a ball-milling promoted, fast, high yielding, and highly enantioselective solvent-free A³ reaction using a reusable catalyst.