Enantioselective, Copper(<scp>I</scp>)‐Catalyzed Three‐Component Reaction for the Preparation of Propargylamines

Abstract

The one-pot reaction of alkynes, aldehydes, and secondary amines in the presence of CuBr/quinap as the catalytic system provides various enantiomerically enriched propargylamines in good yields (up to 99 %) and good selectivities (up to 96 % ee) [Eq. (1)].