Synthesis of a β‐Mannosyl‐Chitobiosyl‐Asparagine Conjugate—a Central Core Region Unit of the <i>N</i>‐Glycoproteins

Abstract

The correct β-glycosidic linkage between mannose and chitobiosyl-asparagine residues in N-glycoproteins was achieved synthetically for the first time in the construction of 1. Decisive is the intramolecular nucleophilic substitution in 2; the product of this reaction was transformed, via a trisaccharide and a trisaccharide isothiocyanate, into the asparagine derivative 1.