Radiology · 2004 · 191 citations · 12 references
MedicineOncologyRadiologyDiagnostic ImagingDiagnostic RadiologyDrug DeliveryHepatobiliary ImagingHepatocellular Carcinoma PharmacotherapyImage-guided TherapyMagnetic Field-responsive Drug DeliveryMagnetic Resonance ImagingMedical ImagingConventional AngiographyFluoroscopic GuidanceIntraprocedural ImagingMagnetic Drug Delivery SystemsMagnetic ResonanceMagnetic Resonance AngiographyMagnetically Guided Drug TargetingTargeted Chemotherapy Using Magnetic Carriers
Four patients with inoperable hepatocellular carcinoma were treated with a magnetic targeted carrier bound to doxorubicin (MTC-DOX) by using a joint magnetic resonance (MR) imaging/conventional angiography system consisting of a 1.5-T short-bore magnet connected to a C-arm angiography unit by a sliding tabletop. Selective transcatheter delivery of the MTC-DOX to the hepatic artery was monitored by using intraprocedural MR imaging, and interim catheter manipulation was performed with fluoroscopic guidance to optimize agent delivery to the tumor and minimize delivery to normal tissue. The final fraction of treated tumor volume ranged from 0.64 to 0.91. The fraction of affected normal liver volume ranged from 0.07 to 0.30. The dual MR imaging/conventional angiography system shows promise for directing magnetically targeted tumor therapies.
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MR Imaging-guided Percutaneous Cryotherapy of Liver Tumors: Initial Experience
Stuart G. Silverman, Kemal Tuncali, D F Adams et al. · Radiology · 2000 · 213 citations