A Type II Polyketide Synthase from the Gram‐Negative Bacterium <i>Stigmatella aurantiaca</i> Is Involved in Aurachin Alkaloid Biosynthesis

Abstract

A closer look: The path for the biosynthesis of aurachin alkaloids (aurachin A is shown) has been deduced by molecular biological methods, including the cloning and sequencing of the biosynthetic gene cluster in the bacterium Stigmatella aurantiaca. The gene cluster encodes a type II polyketide synthase, which was discovered in this form for the first time in a Gram-negative bacterium.