Relationship Between Release of Platelet/Endothelial Biomarkers and Plasma Levels of Sertraline and <i>N</i>-Desmethylsertraline in Acute Coronary Syndrome Patients Receiving SSRI Treatment for Depression

Abstract

This is the first documented evidence that plasma release of platelet/endothelial biomarkers is directly related to the levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. The clinical significance of these findings should be assessed in the setting of a randomized clinical trial.