Coincidence of immune‐mediated diseases driven by Th1 and Th 2 subsets suggests a common aetiology. A population‐based study using computerized General Practice data

Abstract

It is concluded that Th1- and Th2-mediated diseases are significantly associated in a large General Practice population. This finding supports the proposal that autoimmune and atopic diseases share risk factors that increase the propensity of the immune system to generate both Th1- and Th2-mediated inappropriate responses to non-pathological antigens.