Concepedia

Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure

Maciej J. Zamek‐Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley Jackson, Kay Hoong Chow, Denis McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr,

Drug Metabolism and Disposition · 2013 · 39 citations · 24 references

DOIFull text

Open access

Concepts

References

24

A molecular mechanism for the effect of lithium on development.

Peter S. Klein, Douglas A. Melton · Proceedings of the National Academy of Sciences · 1996 · 2.3K citations

, , +11

Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

Michael Martin, Kunal Rehani, Richard S. Jope et al. · Nature Immunology · 2005 · 1.1K citations · Full text

, , +16

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

, , +17

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Zhong Wang, Kevin S. Smith, Mark Murphy et al. · Nature · 2008 · 261 citations

, , +12

Determination of mean valproic acid serum level by assay of a single pooled sample

Robert A. Hamilton, William R. Garnett, Berry J. Kline · Clinical Pharmacology & Therapeutics · 1981 · 256 citations

, , +15