Angeolide, a Novel Lactone from <i>Angelica glauca</i>

Abstract

Abstract The structure and stereochemistry of angeolide (1) , a novel dimeric lactone isolated from Angelica glauca Edgew., have been determined by X‐ray analysis. Angeolide has been found to be the dimer of the butylidenephthalide 2 (ligustilide). The two isomeric ligustilides have been isolated from this plant and their stereochemistry has been determined. The relationship between angeolide (1) and ligustilide has been confirmed by chemical transformation.