Histone deacetylase inhibitor suppression of autoantibody‐mediated arthritis in mice via regulation of p16<sup>INK4a</sup> and p21<sup>WAF1/Cip1</sup> expression - Concepedia

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Histone deacetylase inhibitor suppression of autoantibody‐mediated arthritis in mice via regulation of p16<sup>INK4a</sup> and p21<sup>WAF1/Cip1</sup> expression

214

Citations

48

References

2004

Year

Keiichiro Nishida, Takamitsu Komiyama, Shin‐Ichi Miyazawa, Zheng-Nan Shen, Takayuki Furumatsu, Hideyuki Doi, Aki Yoshida, Jiro Yamana, Masahiro Yamamura, Yoshihumi Ninomiya,

Arthritis & Rheumatism

Abstract

Our findings strongly suggest that systemic administration of HDA inhibitors may represent a novel therapeutic target in RA by means of cell cycle arrest in RASFs via induction of p16INK4a expression and increase in p21(WAF1/Cip1) expression.

References

	Year	Citations

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