Concepedia

A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

NL Cluny, VK Vemuri, AP Chambers, CL Limebeer, H Bedard, JT Wood, Beat Lutz, Andreas Zimmer, LA Parker, A. Makriyannis

British Journal of Pharmacology · 2010 · 189 citations · 48 references

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Abstract

Peripherally active, cannabinoid receptor antagonists with limited brain penetration may be useful agents for the treatment of obesity and its complications.

References

48

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

Jordi Folch, Marjorie B. Lees, G H S Stanley · Journal of Biological Chemistry · 1957 · 64.4K citations · Full text

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

, , +8

Guide to Receptors and Channels (GRAC), 5th edition

S P H Alexander, Alistair Mathie, JA Peters · British Journal of Pharmacology · 2011 · 1.9K citations · Full text

The endogenous cannabinoid system controls extinction of aversive memories

Giovanni Marsicano, Carsten T. Wotjak, Shahnaz Christina Azad et al. · Nature · 2002 · 1.7K citations

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Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

Zoltán Járai, Jens A. Wagner, K Varga et al. · Proceedings of the National Academy of Sciences · 1999 · 595 citations · Full text