Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Jeh-Ping Liu, Julie C. Baker, Archlbald S. Perkins et al. · Cell · 1993 · 2.9K citations

Life Sciences, Developmental Biology, Genetics +16

Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

A. Ullrich, Andrew Gray, Albert W. Tam et al. · The EMBO Journal · 1986 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

Yen‐Yu Lu, Xiaolin Zi, Yuqing Zhao et al. · JNCI Journal of the National Cancer Institute · 2001 · 889 citations · Full text

Medicine, Oncology, Pharmacology +15

Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition

Nikolaos A. Dallas, Ling Xia, Michael J. Gray et al. · Cancer Research · 2009 · 580 citations · Full text

Medicine, Oncology, Pharmacology +17

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

Arnab Chakravarti, Jay S. Loeffler, Nicholas J. Dyson · PubMed · 2002 · 513 citations

Medicine, Oncology, Pharmacology +17