Concepedia

Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway

Joanna Jakóbkiewicz‐Banecka, Ewa Piotrowska, Magdalena Narajczyk, Sylwia Barańska, Grzegorz Węgrzyn

Journal of Biomedical Science · 2009 · 111 citations · 21 references

DOIFull text

Open access

Abstract

The results presented in this report indicate that the mechanism of genistein-mediated inhibition of GAG synthesis operates through epidermal growth factor (EGF)-dependent pathway.

References

21

The metabolic and molecular bases of inherited disease

Ying-Tsong Chen · Medical Entomology and Zoology · 2001 · 6.9K citations

, , +6

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Tetsu Akiyama, Junko Ishida, Shizue Nakagawa et al. · Journal of Biological Chemistry · 1987 · 3.7K citations · Full text

Aliphatic Ammonium Salts in the Assay of Acidic Polysaccharides from Tissues

J. E. Scott · Methods of biochemical analysis · 1960 · 681 citations

, , +15

Enzyme-Replacement Therapy in Mucopolysaccharidosis I

Emil Kakkis, Joseph Muenzer, George E. Tiller et al. · New England Journal of Medicine · 2001 · 670 citations · Full text

A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome)

Joseph Muenzer, J. E. Wraith, Michael Beck et al. · Genetics in Medicine · 2006 · 578 citations · Full text

, , +6