Metronomic Chemotherapy Enhances Antitumor Effects of Cancer Vaccine by Depleting Regulatory T Lymphocytes and Inhibiting Tumor Angiogenesis

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Tyler J. Curiel, George Coukos, Linhua Zou et al. · Nature Medicine · 2004 · 5.1K citations

Life Sciences, Immunology, Oncology +16

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

Giao Q. Phan, James Chih‐Hsin Yang, Richard M. Sherry et al. · Proceedings of the National Academy of Sciences · 2003 · 1.6K citations · Full text

Life Sciences, Immunology, Oncology +17

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

François Ghiringhelli, Cédric Menard, Pierre E. Puig et al. · Cancer Immunology Immunotherapy · 2006 · 1.2K citations · Full text

Life Sciences, Immunology, Oncology +17

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

K Y Lin, Frank Guarnieri, Kevin F. Staveley-O’Carroll et al. · PubMed · 1996 · 1K citations

Medicine, Immunology, Oncology +17

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

Nancy Klauber, Sareh Parangi, Evelyn Flynn et al. · PubMed · 1997 · 527 citations

Medicine, Oncology, Pharmacology +15