Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

Abstract

This study offers insights into the relationship between adult glial progenitors and Proneural GBM, and allows us to identify molecular alterations that lead to more aggressive tumor growth. In addition, we present a new preclinical model that can be used to test treatments directed at a specific type of GBM in future studies.