Contribution of Bone Marrow–Derived Cells Associated With Brain Angiogenesis Is Primarily Through CD69 ⁺

Abstract

Nearly all BMDCs in the angiogenic focus showed expression for leukocytes/macrophages, indicating that BMDCs minimally incorporated into the neovasculature. Colocalization of MMPs with GFP suggests that BMDCs play a critical role in VEGF-induced angiogenic response through up-regulation of MMPs.