Influence of Leptin on Arterial Distensibility

Atul Singhal, I. Sadaf Farooqi, Tim Cole, Stephen O’Rahilly, Mary Fewtrell, Mia Kattenhorn, Alan Lucas, John Deanfield

Circulation · 2002 · 366 citations · 32 references

Abstract

Elevation in leptin was associated with impaired vascular function, independent of the metabolic and inflammatory disturbances associated with obesity. Our observations are consistent with data from experimental models and suggest that high leptin concentration is an important mechanism for the adverse influence of body fatness on CVD.

References

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