British Journal of Cancer · 2011 · 28 citations · 7 references
MedicineInfectious DiseasesUrologyMedical MicrobiologyProstate DiseaseReproductive HealthProstate InfectionProstate InflammationProstate-specific Antigen TestingProstatic PathologySexually Transmitted InfectionsUrinary Tract InfectionsInfectious ProstatitisNonbacterial ProstatitisProstate Disease EpidemiologyProstate Inflammation PhysiologyProstate-specific Antigen DensityProstatic InflammationProstatic Inflammatory MarkersSexually Transmitted Prostatitis
BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. RESULTS: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively). CONCLUSION: Chlamydia and gonorrhoea may infect the prostate of some infected men.
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