Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

D. Gale Johnson, James K. Schwarz, W. Douglas Cress et al. · Nature · 1993 · 953 citations

Life Sciences, Cell Biology, Molecular Biology +15

Long-Term Outcome for Patients With Nonmetastatic Osteosarcoma of the Extremity Treated at the Istituto Ortopedico Rizzoli According to the Istituto Ortopedico Rizzoli/Osteosarcoma-2 Protocol: An Updated Report

Gaetano Bacci, Stefano Ferrari, Franco Bertoni et al. · Journal of Clinical Oncology · 2000 · 447 citations

Medicine, Oncology, Surgery +15

Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome

Nicola Baldini, Katia Scotlandi, Giovanni Barbanti Bròdano et al. · New England Journal of Medicine · 1995 · 399 citations · Full text

Medicine, Oncology, Pathology +6

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

Jill E. Slansky, Y Li, William G. Kaelin et al. · Molecular and Cellular Biology · 1993 · 306 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

Alexandru Almasan, Yuxin Yin, R E Kelly et al. · Proceedings of the National Academy of Sciences · 1995 · 297 citations

Life Sciences, Cell Biology, Molecular Biology +17