Assessing the drug-likeness of lamellarins, a marine-derived natural product class with diverse oncological activities

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11K citations

Development Settings, Pharmaceutical Science, Drug Target +8

A Bioavailability Score

Yvonne C. Martin · Journal of Medicinal Chemistry · 2005 · 947 citations

Bioconcentration, Pharmaceutical Science, Chemical Analysis +18

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

M. Paul Gleeson · Journal of Medicinal Chemistry · 2008 · 934 citations

Engineering, Ionization State, Interpretable Admet Rules +25

Is There a Difference between Leads and Drugs? A Historical Perspective

Tudor I. Oprea, A. M. Davis, Simon J. Teague et al. · Journal of Chemical Information and Computer Sciences · 2001 · 771 citations

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Rosemarie O’Shea, Heinz E. Moser · Journal of Medicinal Chemistry · 2008 · 668 citations

Pharmaceutical Science, Altmetric Attention Score, Organic Chemistry +17