Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

Luc M. Hondeghem, Dirk J. Snyders · Circulation · 1990 · 608 citations · Full text

Reduced Effectiveness, Translational Medicine, Heart Failure +15

Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.

Nancy K. Jurkiewicz, Michael C. Sanguinetti · Circulation Research · 1993 · 518 citations · Full text

Cardiac Muscle, Cardiovascular Pharmacology, Pharmacotherapy +18

Extracellular Potassium Modulation of Drug Block of I_Kr

Tao Yang, Dan M. Roden · Circulation · 1996 · 431 citations

Apico?basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium

N SZENTADRASSY, Tamás Bányász, Gábor Szabó et al. · Cardiovascular Research · 2004 · 182 citations · Full text

Ionic currents and action potentials in rabbit, rat, and guinea pig ventricular myocytes

András Varró, David A. Lathrop, S. B. Hester et al. · Basic Research in Cardiology · 1993 · 161 citations

Cardiac Muscle, Ionic Currents, Molecular Physiology +11