IEEE Transactions on Neural Networks · 1990 · 64 citations · 21 references
Life SciencesBioinformaticsComputer ScienceComputational BiologySequence AnalysisStructural BioinformaticsNucleic Acid ModelingNucleic Acid StructureRna StructureMaximum Independent Set ApproximationNucleic Acid Secondary Structure PredictionParallel Algorithm AnalysisRna Structural ModelingRna Structural MotifsStructure-based Secondary Structure Analysis
A parallel algorithm for finding a near-maximum independent set in a circle graph is presented. An independent set in a graph is a set of vertices, no two of which are adjacent. A maximum independent set is an independent set whose cardinality is the largest among all independent sets of a graph. The algorithm is modified for predicting the secondary structure in ribonucleic acids (RNA). The proposed system, composed of an n neural network array (where n is the number of edges in the circle graph of the number of possible base pairs), not only generates a near-maximum independent set but also predicts the secondary structure of ribonucleic acids within several hundred iteration steps. The simulator discovered several solutions which are more stable structures, in a sequence of 359 bases from the potato spindle tuber viroid, than previously proposed structures.
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A Simple Parallel Algorithm for the Maximal Independent Set Problem
Michael Luby · SIAM Journal on Computing · 1986 · 1.1K citations
Estimation of Secondary Structure in Ribonucleic Acids
Ignacio Tinoco, Olke C. Uhlenbeck, Mark Levine · Nature · 1971 · 696 citations