Clinical drug‐resistant nodular sclerosing Hodgkin's lymphoma is associated with decreased bcl‐2 expression in the surrounding lymphocytes and with increased bcl‐2 expression in the Reed–Sternberg cells

Abstract

A high percentage of Reed-Sternberg cells expressing bcl-2 protein and a low expression of bcl-2 proteifi in the surrounding lymphocytes is associated with treatment-failure, and subsequent poor survival in young patients with nodular sclerosing Hodgkin's lymphoma. These results need further validation in larger studies.