Detection of<i>EGFR</i>Gene Mutation in Lung Cancer by Mutant-Enriched Polymerase Chain Reaction Assay

Abstract

Our results indicate that EGFR mutations are readily detectable by mutant-enriched PCR in various clinical samples. Thus, mutant-enriched PCR may provide a valuable method of potentially detecting a small fraction of mutant genes in heterogeneous specimens, indicating its possible use in clinical application for NSCLC.