Convergent Synthesis of Silylated Allylic Alcohols by a Stereoselective Domino, Sequential Radical-Coupling Reaction

Abstract

The domino, sequential coupling reaction provides a convergent and stereoselective synthetic route for allylic alcohols from carbonyl compounds, alkynes, and alkenes (see scheme). The reaction involves sequential radical coupling reactions initiated by the α-siloxy radicals, which are generated from carbonyl compounds and silyl tellurides.