Residual Chemical Shift Anisotropy (RCSA): A Tool for the Analysis of the Configuration of Small Molecules

Abstract

Together we are strong: A new, robust method allows the measurement of residual chemical shift anisotropies for the determination of conformation and configuration of molecules in organic solvents. The power of the method is shown by the example of estrone and 13-epi-estrone (see structures), where only the combined use of residual chemical shift anisotropies and residual dipolar couplings leads to the distinction of the two diastereomers. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.