Catalytic Enantioselective Conjugate Reduction of β,β‐Disubstituted Nitroalkenes

Abstract

Efficient addition: Bisphosphane–CuI complexes catalyze the enantioselective reduction of β,β-disubstituted nitroalkenes, giving chiral β,β-disubstituted nitroalkanes in useful yields and selectivities (see scheme). The reaction can be carried out with as little as 0.1 mol % of complex, rendering the process among one of the more efficient methods for conjugate addition chemistry. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z52175_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.