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Transforming Growth Factor β1 Is Expressed in the Jejunum after Experimental<i>Cryptosporidium parvum</i>Infection in Humans

Prema Robinson, Pablo C. Okhuysen, Cynthia L. Chappell, Dorothy E. Lewis, Imran Shahab, Sandeep Lahoti, A. Clinton White

Infection and Immunity · 2000 · 40 citations · 19 references

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Abstract

Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.

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