Identification and Characterization of Vascular Calcification–Associated Factor, a Novel Gene Upregulated During Vascular Calcification In Vitro and In Vivo

Abstract

We demonstrate the isolation of a novel gene, VCAF, which is upregulated during vascular calcification in vitro and in vivo. Antisense VCAF gene delivery accelerates pericyte differentiation, implicating a role for VCAF in this clinically significant pathological process.