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In Vitro Activities of Ertapenem (MK-0826) against Clinical Bacterial Isolates from 11 North American Medical Centers

Peter Fuchs, Arthur L. Barry, Steven D. Brown

Antimicrobial Agents and Chemotherapy · 2001 · 98 citations · 7 references

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Abstract

This study compared the in vitro activities of the new long-half-life carbapenem ertapenem (also known as MK-0826 and L-749,345) with those of imipenem, amoxicillin-clavulanate, and ciprofloxacin against 5,558 recent clinical isolates from 11 North American medical centers. We confirmed the greater activity of ertapenem than of imipenem against the Enterobacteriaceae and the greater activity of imipenem against pseudomonads and gram-positive bacteria.

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Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically

Mary Jane Ferraro · 2000 · 16.9K citations

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In Vitro Activities of the Potent, Broad-Spectrum Carbapenem MK-0826 (L-749,345) against Broad-Spectrum β-Lactamase-and Extended-Spectrum β-Lactamase-Producing <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> Clinical Isolates

Joyce Kohler, Karen Dorso, Katherine Young et al. · Antimicrobial Agents and Chemotherapy · 1999 · 79 citations · Full text

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In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbapenem Antibiotic, MK-826 (L-749,345)

Charles Gill, Jesse J. Jackson, Lynn S. Gerckens et al. · Antimicrobial Agents and Chemotherapy · 1998 · 68 citations · Full text

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Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens

George A. Jacoby, P Han, John H. Tran · Antimicrobial Agents and Chemotherapy · 1997 · 53 citations · Full text

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Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates

Jon G. Sundelof, Richard Hajdu, Christopher Gill et al. · Antimicrobial Agents and Chemotherapy · 1997 · 39 citations · Full text

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