Orotic Acid and Related Compounds in the Nutrition of Lactobacillus bulgaricus 09

Abstract

The orotic acid requirement of Lactobacillus bulgaricus 09 can be met by ureidosuccinic acid (10-20% as active as orotic acid) or by 5-(carboxy-methylidine)-hydantoin (30-40% as active as orotic acid but not by any one of a large group of lated or unrelated compounds studied. The data are taken as microbiological evidence that ureidosuccinic acid and possibly ureidofumaric acid (derived from 5-(carboxy-methylidine)-hydantoin) are precursors of the pyrimidine ring.