Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Coronary Artery Disease

Abstract

The present study provides evidence that the Glu(298)-->Asp and T(786)-->C polymorphisms of the eNOS gene are associated with the presence and severity of angiographically defined CAD in the Italian population and that those individuals carrying both eNOS variants simultaneously might have a higher risk of developing CAD.