Aptamer‐Guided Caging for Selective Masking of Protein Domains

Abstract

Lightly unmasked: Large protein subdomains can be masked and photolytically released using aptamers with a suitable photocleavable linker. No structural knowledge of the protein site is needed. Thrombin Exosite I activity can be efficiently regulated with this approach (see scheme), allowing light-controlled activation of blood clotting. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.