Neurogastroenterology & Motility · 2012 · 69 citations · 30 references
The experience of abdominal pain can be experimentally increased or decreased by inducing positive or negative expectations. Nocebo effects involve a psychological stress response, characterized by increased anticipatory anxiety. These findings further underscore the role of cognitive and emotional factors in the experience of visceral pain, which has implications for the pathophysiology and treatment of patients with chronic abdominal complaints.
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Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Ted J. Kaptchuk, John M. Kelley, Lisa Conboy et al. · BMJ · 2008 · 1.2K citations · Full text
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
Ted J. Kaptchuk, Elizabeth Friedlander, John M. Kelley et al. · PLoS ONE · 2010 · 900 citations · Full text