STUDIES ON HORMONAL FACTORS INFLUENCING HEPATIC GLUCOSE-6-PHOSPHATASE¹

Abstract

THE behavior of hepatic glucose-6-phosphatase (G-6-Pase) in various physiological and pathological conditions has recently been under investigation in various laboratories. It was shown that in adult rats and mice, liver G-6-Pase activity increased in fasting (2, 3, 4). On the other hand, G-6-Pase activity progressively decreased in the precancerous liver of 4-dimethylaminoazobenzene fed rats and it was almost completely absent in the developed hepatoma. The transplantable Novikoff rat hepatoma and various transplantable mouse tumors showed no G-6-Pase activity (5). Studies in regenerating liver showed that G-6-Pase activity was not affected in the rapidly growing adult liver. On the other hand, almost no enzymatic activity was demonstrable in 16 and 19 day old rat embryos. Higher than normal G-6-Pase activity was found in the liver of newborn rats (6). These changes in the hepatic G-6-Pase activity under different physiological and pathological conditions have focussed our attention upon the factors whic...