An N‐Heterocyclic Carbene Ligand with Flexible Steric Bulk Allows Suzuki Cross‐Coupling of Sterically Hindered Aryl Chlorides at Room Temperature

Abstract

A juggling act: The steric bulk of the ligand enhances reductive elimination in the Pd-catalyzed Suzuki cross-coupling. However, it impedes the oxidative addition and transmetallation of sterically hindered substrates. This dilemma is solved with the carbene ligand 1, which exhibits flexible steric bulk. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51325_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.